4/14/2023 0 Comments Printable blood pressure log free![]() ![]() The estimated lower dose limit for fatal outcomes is 500–1,000 mg of ingested nicotine for an adult (6.5–13 mg/kg). An average cigarette yields about 2 mg of absorbed nicotine. Animal research suggests that monoamine oxidase inhibitors present in tobacco smoke may enhance nicotine's addictive properties. Slow-release forms (gums and patches, when used correctly) are less addictive and aid in quitting. It functions as an antiherbivore toxin consequently, nicotine was widely used as an insecticide in the past, and neonicotinoids (structurally similar to nicotine), such as imidacloprid, are some of the most effective and widely used insecticides. ![]() Nicotine is also present at ppb-concentrations in edible plants in the family Solanaceae, including potatoes, tomatoes, and eggplants, though sources disagree on whether this has any biological significance to human consumers. Nicotine constitutes approximately 0.6–3.0% of the dry weight of tobacco. Nicotine acts as a receptor agonist at most nicotinic acetylcholine receptors (nAChRs), except at two nicotinic receptor subunits ( nAChRα9 and nAChRα10) where it acts as a receptor antagonist. ![]() ![]() As a pharmaceutical drug, it is used for smoking cessation to relieve withdrawal symptoms. Nicotine is a naturally produced alkaloid in the nightshade family of plants (most predominantly in tobacco and Duboisia hopwoodii) and is widely used recreationally as a stimulant and anxiolytic. ![]()
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